Study confirms HPV genotypes responsible for majority of cervical cancers worldwide
19. 10. 2010 | ecancer.org
Eight human papillomavirus (HPV) types (16, 18, 45, 33, 31, 52, 58, and 35) are responsible for over 90% of all cervical cancer cases worldwide, and should be the target of the next generation vaccines, according to the largest study of HPV genotypes to date, published in The Lancet Oncology [1].
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HPV 16, 18, and 45 are the most common types and occur at a much younger age than other high-risk HPV genotypes. As such, these three HPV types should be the focus of future type-specific HPV screening.
Cervical cancer is the second most common cancer among women worldwide, and is predicted to result in nearly 328 000 deaths in 2010. The disease is caused by high-risk types of HPV. More than 118 different types of HPV have been identified, about 40 of these infect the genital tract, and 12 are known to be cancer causing. To effectively vaccinate against major cancer causing HPV types reliable information on the worldwide contribution of specific types of HPV to invasive cervical cancers is needed, particularly in developing countries where 80% of cases occur.
Read the whole article at ecancer.org
Reference
- Sanjose S, Quint WGV, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncology 2010. doi: 10.1016/S1470-2045(10)70230-8
Keywords: HPV genotypes, cervical cancer
